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Engineering Cases
Engineering Cases
Clarification and Decolorization Project for Fermentation Broth at a Pharmaceutical Company in Chongqing

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Product Introduction:
工艺简述:合成生物学小分子化合物(分子量200-500D)具有多种功能,如红景天抗氧化、增加血氧、抗疲劳;依克多因保湿效果显著;麦角因具有抗氧化和美白效果等。这些化合物通常来源于大肠杆菌发酵液,提取工艺包括陶瓷...
Product Details

Process Brief:
Synthetic biology small-molecule compounds (molecular weight 200–500 D) possess various functions, such as antioxidant activity, increased blood oxygen, and anti-fatigue effects (e.g., Rhodiola rosea); significant moisturizing effects (e.g., ectoine); and antioxidant and whitening properties (e.g., ergothioneine). These compounds are typically derived from E. coli fermentation broth, and the extraction process includes ceramic membrane clarification filtration, decolorization, deproteinization, desalting, concentration, and crystallization. Among these steps, the decolorization process is critical for removing pigments produced by the fermentation medium and bacterial cells, requiring high decolorization efficiency, low product rejection, and high filtration flux.

Technical Advantages:
The process employs organic spiral-wound membrane crossflow filtration technology to achieve efficient decolorization at low temperatures. Through a one-step decolorization and ultra-low pressure filtration approach, it delivers high flux and stable decolorization performance with consistent results. The membrane exhibits superior performance with low rejection of neutral small-molecule functional compounds, ensuring high product yield. Combined with the filtration process, product loss is virtually eliminated.


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