Vancomycin Membrane Extraction System | High-Efficiency Purification · Yield Improvement · Process Upgrading

Vancomycin is a critical antibiotic for the treatment of drug-resistant bacterial infections. Its fermentation broth features complex components and high impurity content. Conventional filtration processes suffer from low yields, insufficient precision, and cumbersome operations. Shandong Qisheng Membrane Separation has integrated ceramic membrane and nanofiltration membrane technologies into the vancomycin extraction process, achieving efficient impurity removal, low-temperature concentration, and clean production, significantly enhancing both product purity and production efficiency.

Process Flow

Fermentation Broth → Ceramic Membrane Ultrafiltration (Impurity Removal) → Nanofiltration Membrane Concentration → Subsequent Purification → Vancomycin Final Product

Ceramic Membrane Ultrafiltration: Efficiently removes mycelium, macromolecular proteins, and metabolites, producing a clear and transparent filtrate.

Nanofiltration Membrane Concentration: Enables high-concentration factor of the target product, reducing the usage of extractants and resins while increasing production capacity.

Technical Advantages

High-Efficiency Impurity Removal with Superior Filtrate Quality – High separation precision significantly reduces impurity content in the filtrate, lessening the load on subsequent purification steps and enhancing crystallization efficiency.

Low-Temperature Operation Preserving Activity – The entire separation process operates at ambient temperatures with no phase change or product degradation, ensuring the bioactivity and stability of vancomycin are fully preserved.

Anti-Fouling Design for Stable Operation – Combining specially designed flow channels with cross-flow technology, the system offers strong fouling resistance, maintains stable membrane flux, and requires minimal maintenance.

Improved Yield and Resource Recycling – Product yield is increased by 5–12% compared to conventional processes. The concentrated mycelium can be recovered as animal feed, enabling resource utilization.

Intelligent Control and Clean Production – Modular design with automated controls reduces manual labor requirements. The closed-system operation complies with GMP standards.

The Qisheng Membrane Extraction System has been successfully deployed in large-scale production of various antibiotics, including vancomycin, cephalosporins, and erythromycin, providing enterprises with efficient, energy-saving, and scalable process solutions. Please contact Shandong Qisheng Membrane Separation Technology Co., Ltd. for technical proposals and project support!